Sterols in asthma

Mireia Guerau-de-Arellano; Rodney D Britt Jr

doi:10.1016/j.it.2022.08.003

Sterols in asthma

Trends Immunol. 2022 Oct;43(10):792-799. doi: 10.1016/j.it.2022.08.003. Epub 2022 Aug 27.

Authors

Mireia Guerau-de-Arellano¹, Rodney D Britt Jr²

Affiliations

¹ School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA; Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, USA; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA; Department of Neuroscience, The Ohio State University, Columbus, OH, USA. Electronic address: mireia.guerau@osumc.edu.
² Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH, USA.

Abstract

While sterols regulate immune processes key to the pathogenesis of asthma, inhibition of sterols with statin drugs has shown conflicting results in human asthma. Here, a novel understanding of the impact of sterols on type 17 immune responses and asthma lead us to hypothesize that sterols and statins may be relevant to severe asthma endotypes with neutrophil infiltration.

Keywords: Th17; asthma; neutrophilic; severe; statin; sterol.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Asthma*
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors* / pharmacology
Hydroxymethylglutaryl-CoA Reductase Inhibitors* / therapeutic use
Sterols

Substances

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Sterols

Abstract

Publication types

MeSH terms

Substances

Grants and funding