Thyroid cancer (TC) is becoming more common all over the world. It is, however, frequently neglected from a scientific standpoint, as they rarely result in a fatal conclusion. The female gender is disproportionately affected, with a frequency of 3 to 5 times higher depending on the severity of the condition, which may or may not cause severe physical discomfort but has a significant influence on life quality. The breakdown of equilibrium between the multiple components that maintain cellular homeostasis may be the cause of the illnesses. On the contrary, excessive or uncontrolled exposure to different hormones, particularly steroids, has been shown to impact the development of thyroid illnesses. The goal of this review is to look at the function of steroids in the expansion and progression of thyroid malignancy (Ref. 54). Keywords: thyroid cancer, signaling, steroid hormone.