Progress in the effect of microRNA-21 on diseases via autophagy

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Jul 28;47(7):936-941. doi: 10.11817/j.issn.1672-7347.2022.210647.
[Article in English, Chinese]

Abstract
in English, Chinese

Autophagy is a regulatory mechanism that packages damaged organelles, proteins, and pathogens to form vesicles and transports to lysosomes for degradation, enabling the recycle of useful components. Therefore, autophagy plays an important role in biological growth regulation and homeostasis. In the past two decades, growing evidence has shown that microRNA (miRNA) is closely related to autophagy. MiRNA-21 promotes or inhibits autophagy via regulating relevant pathways for different downstream target genes, and plays a role in tumors, ischemia-reperfusion injury, and other diseases.

自噬是一种调节机制，它能够把受损的细胞器、蛋白质和病原体包裹形成囊泡，并转运到溶酶体进行降解，让有用成分进行再循环得到重新利用，因此自噬在生物的生长调节和内环境稳态中发挥了重要的功能。在过去二十年中，越来越多的证据显示微RNA(microRNA，miRNA)与自噬紧密相关，miRNA-21通过调控不同下游靶基因激活相关通路，进而促进或抑制自噬，在肿瘤、缺血再灌注损伤等疾病中发挥作用。.

Keywords: autophagy; ischemia-reperfusion injury; microRNA-21; tumor.

MeSH terms

  • Autophagy / genetics
  • Humans
  • Lysosomes / metabolism
  • Lysosomes / pathology
  • MicroRNAs* / metabolism
  • Neoplasms* / pathology
  • Reperfusion Injury* / metabolism

Substances

  • MIRN21 microRNA, human
  • MicroRNAs