New progress in diagnosis and treatment of pulmonary arterial hypertension

J Cardiothorac Surg. 2022 Aug 29;17(1):216. doi: 10.1186/s13019-022-01947-y.

Abstract

Pulmonary arterial hypertension (PAH) is a progressive disease. Although great progress has been made in its diagnosis and treatment in recent years, its mortality rate is still very significant. The pathophysiology and pathogenesis of PAH are complex and involve endothelial dysfunction, chronic inflammation, smooth muscle cell proliferation, pulmonary arteriole occlusion, antiapoptosis and pulmonary vascular remodeling. These factors will accelerate the progression of the disease, leading to poor prognosis. Therefore, accurate etiological diagnosis, treatment and prognosis judgment are particularly important. Here, we systematically review the pathophysiology, diagnosis, genetics, prognosis and treatment of PAH.

Keywords: Biomarker; Genetic; Pathophysiology; Pulmonary arterial hypertension (PAH).

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Animals
  • Cell Proliferation
  • Disease Models, Animal
  • Familial Primary Pulmonary Hypertension
  • Humans
  • Hypertension, Pulmonary* / diagnosis
  • Hypertension, Pulmonary* / pathology
  • Hypertension, Pulmonary* / therapy
  • Muscle, Smooth, Vascular
  • Pulmonary Arterial Hypertension*
  • Pulmonary Artery / pathology