Sanguinarine ameliorates DSS induced ulcerative colitis by inhibiting NLRP3 inflammasome activation and modulating intestinal microbiota in C57BL/6 mice

Affiliations

• ¹ Key Laboratory of Molecular Animal Nutrition of the Ministry of Education, Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang Province, China.
• ² Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, Department of Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, Zhejiang Province, China.
• ³ Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang Province, China.
• ⁴ Department of Intensive Care Unit, the First Affiliated Hospital College of Medicine, Zhejiang University, Hangzhou, 310003, PR China.
• ⁵ Department of Nephrology, Beilun People's Hospital, Ningbo, 315826, Zhejiang Province, China.
• ⁶ Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang Province, China. Electronic address: sfs@zju.edu.cn.
• ⁷ Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, Department of Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, Zhejiang Province, China. Electronic address: 1316056@zju.edu.cn.
• ⁸ Key Laboratory of Molecular Animal Nutrition of the Ministry of Education, Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, Zhejiang Province, China. Electronic address: wfli@zju.edu.cn.