Functional roles of ADP-ribosylation writers, readers and erasers

Ping Li; Yushuang Lei; Jia Qi; Wanqin Liu; Kai Yao

doi:10.3389/fcell.2022.941356

Functional roles of ADP-ribosylation writers, readers and erasers

Front Cell Dev Biol. 2022 Aug 11:10:941356. doi: 10.3389/fcell.2022.941356. eCollection 2022.

Authors

Ping Li¹, Yushuang Lei¹, Jia Qi¹, Wanqin Liu¹, Kai Yao¹

Affiliation

¹ Institute of Visual Neuroscience and Stem Cell Engineering, College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan, China.

Abstract

ADP-ribosylation is a reversible post-translational modification (PTM) tightly regulated by the dynamic interplay between its writers, readers and erasers. As an intricate and versatile PTM, ADP-ribosylation plays critical roles in various physiological and pathological processes. In this review, we discuss the major players involved in the ADP-ribosylation cycle, which may facilitate the investigation of the ADP-ribosylation function and contribute to the understanding and treatment of ADP-ribosylation associated disease.

Keywords: ADP-ribosylation; ARTs; PAR recognition domain; de-ADP-ribosylating enzymes; post-translational modification.

Publication types

Review