Stem cell-derived exosomal transcriptomes for wound healing

Guiling Chen; Hankun Chen; Xiang Zeng; Wei Zhu

doi:10.3389/fsurg.2022.933781

Stem cell-derived exosomal transcriptomes for wound healing

Front Surg. 2022 Aug 12:9:933781. doi: 10.3389/fsurg.2022.933781. eCollection 2022.

Authors

Guiling Chen^{1

2

3

4}, Hankun Chen⁵, Xiang Zeng^{1

2

3

4}, Wei Zhu^{1

2

4}

Affiliations

¹ The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
² The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
³ National Institute of Stem Cell Clinical Research, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.
⁴ Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.
⁵ Research and Development Department, Guangzhou Qinglan Biotechnology Company Limited, Guangzhou, China.

Abstract

Wound healing is a complex and integrated process of the interaction of various components within the injured tissue. Accumulating evidence suggested that stem cell-derived exosomal transcriptomes could serve as key regulatory molecules in wound healing in stem cell therapy. Stem cell-derived exosomal transcriptomes mainly consist of long noncoding RNAs (lncRNAs), microRNAs (miRNAs), circular RNAs (circRNAs) and messenger RNAs (mRNAs). In this article we presented a brief introduction on the wound repair process and exosomal transcriptomes. Meanwhile, we summarized our current knowledge of the involvement of exosomal transcriptomes in physiological and pathological wound repair process including inflammation, angiogenesis, and scar formation.

Keywords: circular RNA; exosome; long noncoding RNA; messenger RNA; microRNA; stem cell; wound healing.

Publication types

Review