[Challenges and limits of therapeutic de-escalation for papillomavirus-related oropharyngeal cancer]

Abstract

The incidence of HPV-related oropharyngeal cancers has been increasing in Western countries for several decades. If they are individualized within the latest TNM classification, the current standards of management do not authorize the management of these patients to be singled out. However, their distinct oncogenesis and their excellent prognosis compared to other patients has allowed the development of several clinical trials based on the question of therapeutic de-escalation. This review of the literature aims to take stock of the elements provided by clinical research in recent years.

Keywords: Cancer de l’oropharynx; Désescalade thérapeutique; Human papillomavirus; Immunotherapy; Immunothérapie; Oropharyngeal cancer; Papillomavirus humain; Radiotherapy; Radiothérapie; Therapeutic de-escalation.