Epigenetic regulation in intervertebral disc degeneration

Gaocai Li; Weifeng Zhang; Huaizhen Liang; Cao Yang

doi:10.1016/j.molmed.2022.07.007

Epigenetic regulation in intervertebral disc degeneration

Trends Mol Med. 2022 Oct;28(10):803-805. doi: 10.1016/j.molmed.2022.07.007. Epub 2022 Aug 24.

Authors

Gaocai Li¹, Weifeng Zhang¹, Huaizhen Liang¹, Cao Yang²

Affiliations

¹ Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, China.
² Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, China. Electronic address: caoyangunion@hust.edu.cn.

PMID: 36030154
DOI: 10.1016/j.molmed.2022.07.007

Abstract

Intervertebral disc (IVD) degeneration is the leading cause of low back pain, which has a striking impact on numerous patients. Therefore, comprehensively illuminating the regulatory mechanisms of IVD degeneration is of great significance. Here, we discuss the latest advances in understanding the main epigenetic mechanisms regulating IVD degeneration.

Keywords: DNA methylation; RNA methylation; epigenetic regulation; histone modification; intervertebral disc degeneration; nucleus pulposus cell.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Epigenesis, Genetic
Humans
Intervertebral Disc Degeneration* / genetics
Intervertebral Disc*