Orbital solitary fibrous tumours: clinicopathological characteristics and recurrence prediction

Graefes Arch Clin Exp Ophthalmol. 2023 Jan;261(1):223-231. doi: 10.1007/s00417-022-05795-3. Epub 2022 Aug 27.

Abstract

Background: SFTs are thought to have an unpredictable clinical course and currently have no recognized prognostic criterion. Our study aimed to determine the relationship between clinicopathological characteristics and the prognosis of patients with orbital SFTs.

Methods: The clinicopathological features of these patients were extracted from clinical records. The relationships between these features and prognosis were analysed.

Results: The positive rates of CD34, CD99, Blc2, and STAT6 expression were 90.3%, 90.3%, 83.9%, and 100%, respectively. The tumour recurrence rate was 38.7%. A higher recurrence rate was observed in patients with Ki67 index ≥ 5 (56.25% vs. 20%, P = 0.038).

Conclusion: A Ki67 index ≥ 5 was an effective parameter for predicting tumour recurrence of orbital SFTs. Close follow-up is needed for these patients.

Keywords: Clinicopathological characteristics; Ki67; Orbit; Recurrence prediction; Solitary fibrous tumour.

MeSH terms

  • Biomarkers, Tumor
  • Hemangiopericytoma* / pathology
  • Humans
  • Ki-67 Antigen
  • Neoplasm Recurrence, Local / epidemiology
  • Neoplasm Recurrence, Local / pathology
  • Severe Fever with Thrombocytopenia Syndrome*
  • Solitary Fibrous Tumors* / diagnosis
  • Solitary Fibrous Tumors* / metabolism
  • Solitary Fibrous Tumors* / surgery

Substances

  • Ki-67 Antigen
  • Biomarkers, Tumor