Emerging Role of Long Non‑coding RNAs in Asthma

Xue-Fen Chen; Jing-Min Deng

doi:10.2174/1386207325666220825152237

Emerging Role of Long Non‑coding RNAs in Asthma

Comb Chem High Throughput Screen. 2023;26(2):247-255. doi: 10.2174/1386207325666220825152237.

Authors

Xue-Fen Chen¹, Jing-Min Deng¹

Affiliation

¹ Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China.

PMID: 36028961
DOI: 10.2174/1386207325666220825152237

Abstract

Asthma is a common complex disorder characterized by hyper-responsiveness and chronic inflammatory airway disease in children and adults worldwide. The prevalence of asthma is increasing with each passing year. Long non-coding RNAs (lncRNAs), regarded as a potentially promising path, have received increasing attention in exploring the biological regulation of chronic airway diseases, although they have no or limited protein-coding capacity. This review highlights the functional roles and clinical significance of lncRNAs in the pathogenesis of asthma and provides directions for diagnosing and treating asthma in the future.

Keywords: Asthma; biomarker; chromation; long non‑coding RNA; molecular mechanism; therapeutic target.

Publication types

Review

MeSH terms

Adult
Asthma* / diagnosis
Asthma* / genetics
Child
Humans
Pulmonary Disease, Chronic Obstructive*
RNA, Long Noncoding* / genetics

Substances

RNA, Long Noncoding

Supplementary concepts

Pulmonary Disease, Chronic Obstructive, Severe Early-Onset