Therapeutic Effect of Melatonin in Premature Ovarian Insufficiency: Hippo Pathway Is Involved

Ming Kang Qi; Tie Cheng Sun; Li Ya Yang; Jia Lin He; Yi Ming Guo; Han Bi Wang; Hui Ping Wang

doi:10.1155/2022/3425877

Therapeutic Effect of Melatonin in Premature Ovarian Insufficiency: Hippo Pathway Is Involved

Oxid Med Cell Longev. 2022 Aug 16:2022:3425877. doi: 10.1155/2022/3425877. eCollection 2022.

Authors

Ming Kang Qi^{1

2}, Tie Cheng Sun³, Li Ya Yang², Jia Lin He^{1

2}, Yi Ming Guo^{1

2}, Han Bi Wang⁴, Hui Ping Wang^{1

2}

Affiliations

¹ Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
² NHC Key Laboratory of Reproductive Health Engineering Technology Research (NRIFP), National Research Institute for Family Planning, Beijing 100081, China.
³ Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University International Hospital, Beijing 102206, China.
⁴ Department of Obstetrics & Gynecology, National Clinical Research Center for Obstetric & Gynecologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China.

Abstract

Objective: Premature ovarian insufficiency (POI) is a female reproductive disorder of unknown etiology with no definite pathogenesis. Melatonin (MT) is an endogenous hormone synthesized mainly by pineal cells and has strong endogenous effects in regulating ovarian function. To systematically explore the pharmacological mechanism of MT on POI therapy, a literature review approach was conducted at the signaling pathways level.

Methods: Relevant literatures were searched and downloaded from databases, including PubMed and China National Knowledge Infrastructure, using the keywords "premature ovarian insufficiency," "Hippo signaling pathways," and "melatonin." The search criteria were from 2010 to 2022. Text mining was also performed.

Results: MT is involved in the regulation of Hippo signaling pathway in a variety of modes and has been correlated with ovarian function.

Conclusions: The purpose of this review is to summarize the research progress of Hippo signaling pathways and significance of MT in POI, the potential crosstalk between MT and Hippo signaling pathways, and the prospective therapy.

Publication types

Review

MeSH terms

China
Female
Hippo Signaling Pathway
Humans
Melatonin* / pharmacology
Melatonin* / therapeutic use
Primary Ovarian Insufficiency* / drug therapy
Signal Transduction

Substances

Melatonin