Neuromodulation of OCD: A review of invasive and non-invasive methods

Alexandra Kammen; Jonathon Cavaleri; Jordan Lam; Adam C Frank; Xenos Mason; Wooseong Choi; Marisa Penn; Kaevon Brasfield; Barbara Van Noppen; Stuart B Murray; Darrin Jason Lee

doi:10.3389/fneur.2022.909264

Neuromodulation of OCD: A review of invasive and non-invasive methods

Front Neurol. 2022 Aug 9:13:909264. doi: 10.3389/fneur.2022.909264. eCollection 2022.

Authors

Affiliations

¹ Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
² Department of Neurosurgery, University of Michigan, Ann Arbor, MI, United States.
³ Department of Psychiatry, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
⁴ Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
⁵ Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.

Abstract

Early research into neural correlates of obsessive compulsive disorder (OCD) has focused on individual components, several network-based models have emerged from more recent data on dysfunction within brain networks, including the the lateral orbitofrontal cortex (lOFC)-ventromedial caudate, limbic, salience, and default mode networks. Moreover, the interplay between multiple brain networks has been increasingly recognized. As the understanding of the neural circuitry underlying the pathophysiology of OCD continues to evolve, so will too our ability to specifically target these networks using invasive and noninvasive methods. This review discusses the rationale for and theory behind neuromodulation in the treatment of OCD.

Keywords: TMS; VNS; deep brain stimulation (DBS); neuromodulation; obsessive compulsive disorder (OCD).

Publication types

Review