Progress of Research into Novel Drugs and Potential Drug Targets against Porcine Pseudorabies Virus

Viruses. 2022 Aug 11;14(8):1753. doi: 10.3390/v14081753.

Abstract

Pseudorabies virus (PRV) is the causative agent of pseudorabies (PR), infecting most mammals and some birds. It has been prevalent around the world and caused huge economic losses to the swine industry since its discovery. At present, the prevention of PRV is mainly through vaccination; there are few specific antivirals against PRV, but it is possible to treat PRV infection effectively with drugs. In recent years, some drugs have been reported to treat PR; however, the variety of anti-pseudorabies drugs is limited, and the underlying mechanism of the antiviral effect of some drugs is unclear. Therefore, it is necessary to explore new drug targets for PRV and develop economic and efficient drug resources for prevention and control of PRV. This review will focus on the research progress in drugs and drug targets against PRV in recent years, and discuss the future research prospects of anti-PRV drugs.

Keywords: drug targets; drugs; prevention; pseudorabies virus; treatment.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / pharmacology
  • Antiviral Agents / therapeutic use
  • Herpesvirus 1, Suid*
  • Mammals
  • Pseudorabies* / drug therapy
  • Pseudorabies* / prevention & control
  • Swine
  • Swine Diseases* / drug therapy
  • Swine Diseases* / prevention & control
  • Vaccination

Substances

  • Antiviral Agents

Grants and funding

This research was funded by a grant from the key project of Jiangsu Province’s Key Research and Development plan (modern Agriculture) (BE2020407), Jiangsu Province high education connotation construction fund (00000221010) and the project of Jiangsu Agri-animal Husbandry Vocational College (NSF2022CB04, NSF2022CB25).