Production Review of Accelerator-Based Medical Isotopes

Yiwei Wang; Daiyuan Chen; Ricardo Dos Santos Augusto; Jixin Liang; Zhi Qin; Juntao Liu; Zhiyi Liu

doi:10.3390/molecules27165294

Production Review of Accelerator-Based Medical Isotopes

Molecules. 2022 Aug 19;27(16):5294. doi: 10.3390/molecules27165294.

Authors

Yiwei Wang¹, Daiyuan Chen¹, Ricardo Dos Santos Augusto², Jixin Liang³, Zhi Qin⁴, Juntao Liu^{1

5}, Zhiyi Liu^{1

5}

Affiliations

¹ School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000, China.
² Brookhaven National Laboratory, United States Department of Energy Upton, New York, NY 11973-5000, USA.
³ Department of Nuclear Technology and Application, China Institute of Atomic Energy, Beijing 102413, China.
⁴ Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
⁵ Frontiers Science Center for Rare Isotopes, Lanzhou University, Lanzhou 730000, China.

Abstract

The production of reactor-based medical isotopes is fragile, which has meant supply shortages from time to time. This paper reviews alternative production methods in the form of cyclotrons, linear accelerators and neutron generators. Finally, the status of the production of medical isotopes in China is described.

Keywords: accelerator; medical isotope production; nuclear medicine; review.

Publication types

Review

MeSH terms

China
Cyclotrons*
Isotopes
Neutrons
Particle Accelerators
Radioisotopes*

Substances

Isotopes
Radioisotopes

Grants and funding

This research was funded by the National natural Science Foundation of China, grant number 11975115; Special Projects of the Central Government in Guidance of Local Science and Technology Development (Research and development of three-dimensional prospecting technology based on Cosmic-ray muons), grant number YDZX20216200001297; the Research and Development of Medical Isotopes based on High-current Superconducting Linear Accelerator Project, the Fundamental Research Funds for the Central Universities, grant number lzujbky-2019-54; the Science and Technology Planning Project of Gansu, grant number 20JR10RA645; Lanzhou University Talent Cooperation Research Funds sponsored by Lanzhou City, grant number 561121203 and Gansu provincial science and technology plan projects for talents, grant number 054000029.