Second- and Third-Tier Therapies for Severe Traumatic Brain Injury

J Clin Med. 2022 Aug 16;11(16):4790. doi: 10.3390/jcm11164790.

Abstract

Intracranial hypertension is a common finding in patients with severe traumatic brain injury. These patients need treatment in the intensive care unit, where intracranial pressure monitoring and, whenever possible, multimodal neuromonitoring can be applied. A three-tier approach is suggested in current recommendations, in which higher-tier therapies have more significant side effects. In this review, we explain the rationale for this approach, and analyze the benefits and risks of each therapeutic modality. Finally, we discuss, based on the most recent recommendations, how this approach can be adapted in low- and middle-income countries, where available resources are limited.

Keywords: brain trauma; intracranial hypertension; neuromonitoring.

Publication types

  • Review

Grants and funding

This research received no external funding.