New insights into the role of circular RNAs in ovarian cancer

Yijuan Xing; Xiaolei Liang; Xiao Lv; Yuemei Cheng; Junhong Du; Chang Liu; Yongxiu Yang

doi:10.1016/j.prp.2022.154073

New insights into the role of circular RNAs in ovarian cancer

Pathol Res Pract. 2022 Oct:238:154073. doi: 10.1016/j.prp.2022.154073. Epub 2022 Aug 13.

Authors

Yijuan Xing¹, Xiaolei Liang², Xiao Lv², Yuemei Cheng¹, Junhong Du¹, Chang Liu², Yongxiu Yang³

Affiliations

¹ The First Clinical Medical College of Lanzhou University, Lanzhou 730000 Gansu, China; Department of Obstetrics and Gynecology, First Hospital of Lanzhou University, Key Laboratory of Gynecologic Oncology Gansu Province, Lanzhou 730000, Gansu, China.
² Department of Obstetrics and Gynecology, First Hospital of Lanzhou University, Key Laboratory of Gynecologic Oncology Gansu Province, Lanzhou 730000, Gansu, China; Department of Obstetrics and Gynecology, First Hospital of Lanzhou University, Lanzhou 730000 Gansu, China.
³ Department of Obstetrics and Gynecology, First Hospital of Lanzhou University, Key Laboratory of Gynecologic Oncology Gansu Province, Lanzhou 730000, Gansu, China; Department of Obstetrics and Gynecology, First Hospital of Lanzhou University, Lanzhou 730000 Gansu, China. Electronic address: yxyanglzu@163.com.

PMID: 36007396
DOI: 10.1016/j.prp.2022.154073

Abstract

Ovarian cancer (OC) is one of the most aggressive tumors in women and has a poor prognosis and the highest mortality rate. Circular RNAs (circRNAs) are a type of endogenous non-coding RNAs that have recently attracted interest in cancer research. Increasing evidence has demonstrated that circRNAs play an oncogenic or suppressive role in tumorigenesis and progression, and show tissue- or developmental-stage-specific expression. Due to high stability, conservation, abundance, and specificity, circRNAs are considered promising biomarkers for the diagnosis and prognosis of cancer. Herein, we have summarized the expression profiles of circRNAs in OC tissues, serums, and cell lines. Moreover, we discuss how circRNAs participate in the regulation of multiple biological processes in OC, including cell proliferation, apoptosis, migration, invasion, autophagy, epithelial-to-mesenchymal transition, glucose metabolism, angiogenesis, immune response, and chemotherapy resistance, by sponging microRNAs and interacting with proteins.

Keywords: Biological function; Circular RNA; Expression; MicroRNA; Ovarian cancer.

Publication types

Review