Abstract
Dll1+ breast cancer cells activate Notch signaling in cancer-associated fibroblasts that increases Wnt ligand secretion and leads to β-catenin-driven radioresistance and metastasis, opening new therapeutic avenues for breast cancer.
©2022 American Association for Cancer Research.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, Non-U.S. Gov't
MeSH terms
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Breast Neoplasms* / pathology
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Breast Neoplasms* / radiotherapy
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Cancer-Associated Fibroblasts* / pathology
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Female
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Humans
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Intercellular Signaling Peptides and Proteins
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Ligands
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Receptors, Notch
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beta Catenin
Substances
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Intercellular Signaling Peptides and Proteins
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Ligands
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Receptors, Notch
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beta Catenin