Dll1-Mediated Notch Signaling Drives Tumor Cell Cross-talk with Cancer-Associated Fibroblasts to Promote Radioresistance in Breast Cancer

Cancer Res. 2022 Oct 17;82(20):3718-3733. doi: 10.1158/0008-5472.CAN-21-1225.

Abstract

Dll1+ breast cancer cells activate Notch signaling in cancer-associated fibroblasts that increases Wnt ligand secretion and leads to β-catenin-driven radioresistance and metastasis, opening new therapeutic avenues for breast cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms* / pathology
  • Breast Neoplasms* / radiotherapy
  • Cancer-Associated Fibroblasts* / pathology
  • Female
  • Humans
  • Intercellular Signaling Peptides and Proteins
  • Ligands
  • Receptors, Notch
  • beta Catenin

Substances

  • Intercellular Signaling Peptides and Proteins
  • Ligands
  • Receptors, Notch
  • beta Catenin