Subversion of autophagy machinery and organelle-specific autophagy by SARS-CoV-2 and coronaviruses

Qinqin Sun; Xiaojuan Li; Ersheng Kuang

doi:10.1080/15548627.2022.2116677

Subversion of autophagy machinery and organelle-specific autophagy by SARS-CoV-2 and coronaviruses

Autophagy. 2023 Apr;19(4):1055-1069. doi: 10.1080/15548627.2022.2116677. Epub 2022 Aug 31.

Authors

Qinqin Sun¹, Xiaojuan Li², Ersheng Kuang^{1

3}

Affiliations

¹ Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.
² College of Clinic Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei, China.
³ Ministry of Education, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Guangzhou, Guangdong, China.

Abstract

As a new emerging severe coronavirus, the knowledge on the SARS-CoV-2 and COVID-19 remains very limited, whereas many concepts can be learned from the homologous coronaviruses. Macroautophagy/autophagy is finely regulated by SARS-CoV-2 infection and plays important roles in SARS-CoV-2 infection and pathogenesis. This review will explore the subversion and mechanism of the autophagy-related machinery, vacuoles and organelle-specific autophagy during infection of SARS-CoV-2 and coronaviruses to provide meaningful insights into the autophagy-related therapeutic strategies for infectious diseases of SARS-CoV-2 and coronaviruses.

Keywords: Autophagy; SARS-CoV-2; coronaviruses; infection; organelle-specific autophagy; replication.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Autophagy
COVID-19* / pathology
Humans
Macroautophagy
Organelles
SARS-CoV-2*

Grants and funding

The work was supported by the National Natural Science Foundation of China [81871643]; National Natural Science Foundation of China [81971928] National Natural Science Foundation of China [32061143008].