The unique effect of TDP-43 on hippocampal subfield morphometry and cognition

Abstract

1. •

   We explored postmortem TDP-43 burden and antemortem hippocampal surface deformation.

2. •

   TDP-43 was uniquely associated with inward deformation in the hippocampus.

3. •

   Deformation patterns account for co-existing disease showing TDP-43′s unique effect.

4. •

   Deformation was significantly correlated with cognition scores.