Charting the neural circuits disruption in inhibitory control and its subcomponents across psychiatric disorders: A neuroimaging meta-analysis

Haifeng Yan; Way K W Lau; Simon B Eickhoff; Jixin Long; Xiaoqi Song; Chanyu Wang; Jiubo Zhao; Xiangang Feng; Ruiwang Huang; Maosheng Wang; Xiaoyuan Zhang; Ruibin Zhang

doi:10.1016/j.pnpbp.2022.110618

Charting the neural circuits disruption in inhibitory control and its subcomponents across psychiatric disorders: A neuroimaging meta-analysis

Prog Neuropsychopharmacol Biol Psychiatry. 2022 Dec 20:119:110618. doi: 10.1016/j.pnpbp.2022.110618. Epub 2022 Aug 21.

Authors

Haifeng Yan¹, Way K W Lau², Simon B Eickhoff³, Jixin Long⁴, Xiaoqi Song⁴, Chanyu Wang⁴, Jiubo Zhao⁵, Xiangang Feng⁵, Ruiwang Huang⁶, Maosheng Wang⁷, Xiaoyuan Zhang⁸, Ruibin Zhang⁹

Affiliations

¹ Cognitive Control and Brain Healthy Laboratory, Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, PR China; Department of Science and Education, The People's Hospital of Gaozhou, Gaozhou, PR China.
² Department of Special Education and Counselling, The Education University of Hong Kong, Hong Kong, PR China.
³ Institute of Neuroscience and Medicine, Brain and Behavior (INM-7), Research Center Jüelich, Germany; Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Germany.
⁴ Cognitive Control and Brain Healthy Laboratory, Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, PR China.
⁵ Cognitive Control and Brain Healthy Laboratory, Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, PR China; Department of Psychiatry, Zhujiang Hospital of Southern Medical University, Guangzhou, PR China.
⁶ School of Psychology, South China Normal University, Guangzhou, PR China.
⁷ Department of Science and Education, The People's Hospital of Gaozhou, Gaozhou, PR China.
⁸ Cognitive Control and Brain Healthy Laboratory, Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, PR China; Department of Psychiatry, Zhujiang Hospital of Southern Medical University, Guangzhou, PR China. Electronic address: zhxy@smu.edu.cn.
⁹ Cognitive Control and Brain Healthy Laboratory, Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, PR China; Department of Psychiatry, Zhujiang Hospital of Southern Medical University, Guangzhou, PR China. Electronic address: ruibinzhang@foxmail.com.

PMID: 36002101
DOI: 10.1016/j.pnpbp.2022.110618

Abstract

Background: Inhibitory control, comprising cognitive inhibition and response inhibition, showed consistent deficits among several major psychiatric disorders. We aim to identify the trans-diagnostic convergence of neuroimaging abnormalities underlying inhibitory control across psychiatric disorders.

Methods: Inhibitory control tasks neuroimaging, including functional magnetic resonance imaging, single-photon emission computed tomography, and positron emission tomography articles published in PubMed and Web of Science before April 2020 comparing healthy controls with patients with several psychiatric disorders were searched.

Results: 146 experiments on 2653 patients with different disorders and 2764 control participants were included. Coordinates of case-control differences coded by diagnosis and inhibitory control components were analyzed using activation likelihood estimation. A robust trans-diagnostic pattern of aberrant brain activation in the bilateral cingulate gyri extending to medial frontal gyri, right insula, bilateral lentiform nuclei, right inferior frontal gyrus, right precuneus extending to inferior parietal lobule, and right supplementary motor area were detected. Frontostriatal pathways are the commonly disrupted neural circuits in the inhibitory control across psychiatric disorders. Furthermore, Patients showed aberrant activation in the dorsal frontal inhibitory system in cognitive inhibition, while in the frontostriatal system in response inhibition across disorders.

Conclusion: Consistent with the Research Domain Criteria initiative, current findings show that psychiatric disorders may be productively formulated as a phenotype of trans-diagnostic neurocircuit disruption. Our results provide new insights for future research into mental disorders with inhibition-related dysfunctions.

Keywords: Inhibitory control; Neuroimaging; Psychiatric disorders; Trans-diagnosis; meta-analysis.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Brain / pathology
Brain Mapping
Humans
Magnetic Resonance Imaging
Mental Disorders*
Neuroimaging*
Positron-Emission Tomography