Diabetic kidney disease (DKD) is a severe microvascular complication of diabetes mellitus. It is the leading inducement of end-stage renal disease (ESRD), and its global incidence has been increasing at an alarming rate. The strict control of blood pressure and blood glucose can delay the progression of DKD, but intensive treatment is challenging to maintain. Studies to date have failed to find a complete cure. The glomerulus's alterations and injuries play a pivotal role in the initiation and development of DKD. A wealth of data indicates that the interdependent relationship between resident cells in the glomerulus will provide clues to the mechanism of DKD and new ways for therapeutic intervention. This review summarizes the significant findings of glomerular cell cross talk in DKD, focusing on cellular signaling pathways, regulators, and potential novel avenues for treating progressive DKD.
糖尿病肾病(DKD)是糖尿病(DM)的一种严重微血管并发症。它是终末期肾病(ESRD)的主要诱因, 其全球发病率一直在以惊人的速度增加。严格控制血压和血糖可以延缓DKD的进展, 但强化治疗很难维持。到目前为止, 还没有找到完全治愈的方法。肾小球的改变和损伤在DKD 的发生和发展中起着关键作用。大量数据表明, 肾小球内驻留细胞之间的相互作用关系将为DKD的发病机制提供线索, 为治疗干预提供新的途径。本文综述了肾小球细胞相互作用在DKD中的重要研究结果, 重点介绍了对细胞信号通路、调节因子和DKD潜在新途径的研究进展。.
Keywords: cell cross talk; diabetic kidney disease; glomerulus; 糖尿病肾病; 细胞相互作用; 肾小球.
© 2022 The Authors. Journal of Diabetes published by Ruijin Hospital, Shanghai JiaoTong University School of Medicine and John Wiley & Sons Australia, Ltd.