Odorant receptors as potential drug targets

Rafaella G Naressi; Deborah Schechtman; Bettina Malnic

doi:10.1016/j.tips.2022.08.003

Odorant receptors as potential drug targets

Trends Pharmacol Sci. 2023 Jan;44(1):11-14. doi: 10.1016/j.tips.2022.08.003. Epub 2022 Aug 20.

Authors

Rafaella G Naressi¹, Deborah Schechtman¹, Bettina Malnic²

Affiliations

¹ Department of Biochemistry, University of São Paulo, São Paulo, Brazil.
² Department of Biochemistry, University of São Paulo, São Paulo, Brazil. Electronic address: bmalnic@iq.usp.br.

PMID: 35999088
DOI: 10.1016/j.tips.2022.08.003

Abstract

Odorant receptors (ORs) belong to a large family of G protein-coupled receptors (GPCRs) that are highly expressed by olfactory sensory neurons of the nose. Accumulating evidence indicates that they are also expressed in a variety of nonolfactory tissues, which makes them new potential drug targets. Here we discuss the challenges and strategies to target these receptors.

Keywords: GPCRs; drug; ectopic; odorant receptors; target.

MeSH terms

Humans
Olfactory Receptor Neurons*
Receptors, G-Protein-Coupled
Receptors, Odorant*

Substances

Receptors, Odorant
Receptors, G-Protein-Coupled