Sesquiterpene coumarins isolated from Ferula bungeana and their anti-neuroinflammatory activities

Tingting Guo; Wen Dang; Yaping Zhou; Di Zhou; Qingqi Meng; Libin Xu; Gang Chen; Bin Lin; Degang Qing; Yu Sun; Yue Hou; Ning Li

doi:10.1016/j.bioorg.2022.106102

Sesquiterpene coumarins isolated from Ferula bungeana and their anti-neuroinflammatory activities

Bioorg Chem. 2022 Nov:128:106102. doi: 10.1016/j.bioorg.2022.106102. Epub 2022 Aug 18.

Authors

Tingting Guo¹, Wen Dang¹, Yaping Zhou¹, Di Zhou¹, Qingqi Meng², Libin Xu², Gang Chen¹, Bin Lin³, Degang Qing⁴, Yu Sun⁴, Yue Hou⁵, Ning Li⁶

Affiliations

¹ School of Traditional Chinese Materia Medica, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, China.
² College of Life and Health Sciences, Northeastern University, Shenyang 110004, China; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, China.
³ School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
⁴ XinJiang Institute of Chinese Materia Medica and Ethnodrug, Urumqi, China.
⁵ College of Life and Health Sciences, Northeastern University, Shenyang 110004, China; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, China. Electronic address: houyue@mail.neu.edu.cn.
⁶ School of Traditional Chinese Materia Medica, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: liningsypharm@163.com.

PMID: 35998519
DOI: 10.1016/j.bioorg.2022.106102

Abstract

This is the first study to profile natural sesquiterpene coumarins (SCs) in Ferula bungeana, a medicinal plant of the genus Ferula in China. Eight undescribed sesquiterpene coumarins (1-8), along with six known ones (9-14) were obtained from the whole plant of F. bungeana. These unreported SCs (1-8) enriched the structural diversity of natural SCs, especially these with the hydroxy or carbonyl group at C-7' and a hydroperoxy group at C-7' or C-8'. Compounds (9-14) were reported for the first time from this plant. The in vitro anti-neuroinflammatory activity assay showed that compounds 2 and 9 showed stronger inhibitory effect on nitric oxide (NO) production in lipopolysaccharide (LPS)-induced BV-2 microglia, compared with positive control minocycline, and compounds 5 and 10 showed moderate inhibitory effects.

Keywords: BV-2 microglia; Ferula bungeana; Neuroinflammation; Sesquiterpene coumarins.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Coumarins / chemistry
Coumarins / pharmacology
Ferula* / chemistry
Lipopolysaccharides / pharmacology
Nitric Oxide
Sesquiterpenes* / chemistry
Sesquiterpenes* / pharmacology

Substances

Coumarins
Lipopolysaccharides
Sesquiterpenes
Nitric Oxide