Recent advances in polysaccharide-based in situ forming hydrogels

Junyi Chen; Zhenghao Zhai; Kevin J Edgar

doi:10.1016/j.cbpa.2022.102200

Recent advances in polysaccharide-based in situ forming hydrogels

Curr Opin Chem Biol. 2022 Oct:70:102200. doi: 10.1016/j.cbpa.2022.102200. Epub 2022 Aug 20.

Authors

Junyi Chen¹, Zhenghao Zhai², Kevin J Edgar³

Affiliations

¹ School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.
² Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA 24061, United States.
³ Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA 24061, United States; Department of Sustainable Biomaterials, Virginia Tech, Blacksburg, VA 24061, United States. Electronic address: kjedgar@vt.edu.

PMID: 35998387
DOI: 10.1016/j.cbpa.2022.102200

Abstract

Polysaccharides comprise an important class of natural polymers; they are abundant, diverse, polyfunctional, typically benign, and are biodegradable. Using polysaccharides to design in situ forming hydrogels is an attractive and important field of study since many polysaccharide-based hydrogels exhibit desirable characteristics including self-healing, responsiveness to environmental stimuli, and injectability. These characteristics are particularly useful for biomedical applications. This review will discuss recent discoveries in polysaccharide-based in situ forming hydrogels, including network architecture designs, curing mechanisms, physical and chemical properties, and potential applications.

Keywords: Benign; Biodegradable; Hydrogels; In situ forming; Injectable; Polysaccharides; Self-healing.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Hydrogels* / chemistry
Polymers / chemistry
Polysaccharides* / chemistry

Substances

Hydrogels
Polymers
Polysaccharides