Experimental Infection of Peromyscus Species Rodents with Sin Nombre Virus

Emerg Infect Dis. 2022 Sep;28(9):1882-1885. doi: 10.3201/eid2809.220509.

Abstract

We demonstrate that 6 distinct Peromyscus rodent species are permissive to experimental infection with Sin Nombre orthohantavirus (SNV). Viral RNA and SNV antibodies were detected in members of all 6 species. P. leucopus mice demonstrated markedly higher viral and antibody titers than P. maniculatus mice, the established primary hosts for SNV.

Keywords: Orthohantaviruses; Peromyscus; Peromyscus leucopus; Peromyscus maniculatus; Sin Nombre virus; hantavirus cardiopulmonary syndrome; rodents; viruses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Viral
  • Hantavirus Pulmonary Syndrome*
  • Peromyscus
  • RNA, Viral
  • Rodentia
  • Sin Nombre virus* / genetics

Substances

  • Antibodies, Viral
  • RNA, Viral