To grow food for people, antibiotics were used, and these antibiotics can accumulate in the human body through food metabolism, which may have remarkably harmful effects on human health and safety. Therefore, low-cost sensors are needed for the detection of antibiotic residues in food samples. Recently, nanomaterial-based electrochemical sensors such as carbon nanoparticles, graphene nanoparticles, metal oxide nanoparticles, metal nanoparticles, and metal-organic nanostructures have been successfully used as sensing materials for the detection of chloramphenicol (CP) and furazolidone (FZ) antibiotics. However, additional efforts are still needed to fabricate effective multi-functional nanomaterial-based electrodes for the preparation of portable electrochemical sensor devices. The current review focuses on a quick introduction to CP and FZ antibiotics, followed by an outline of the current electrochemical analytical methods. In addition, we have discussed in-depth different nanoparticle supports for the electrochemical detection of CP and FZ in different matrices such as food, environmental, and biological samples. Finally, a summary of the current problems and future perspectives in this area are also highlighted.