Choroidal Osteoma with Choroidal Neovascular Membrane treated with Anti- vascular Endothelial Growth Factor: A Rare Case with Review of Literatures

Nepal J Ophthalmol. 2021 Jul;13(24):196-201. doi: 10.3126/nepjoph.v13i2.33218.

Abstract

Introduction: Choroidal osteoma, usually unilateral, is a rare benign tumor of choroid. It is predominantly seen in young females.

Case: We report a case of a 35-year-old female with unilateral choroidal osteoma associated with choroidal neovascular membrane (CNVM). The diagnosis was confirmed with clinical examination, ocular ultrasonography, fundus fluorescein angiography and macular optical coherence tomography. Choroidal neovascular membrane improved with 3 doses of bevacizumab, an anti-vascular endothelial growth factors (Anti-VEGF).

Conclusion: Anti-VEGF monotherapy can be a cost effective primary modality of treatment for choroidal neovascular membrane secondary to choroidal osteoma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Angiogenesis Inhibitors
  • Bevacizumab
  • Choroid
  • Choroid Neoplasms* / complications
  • Choroid Neoplasms* / diagnosis
  • Choroid Neoplasms* / drug therapy
  • Choroidal Neovascularization* / diagnosis
  • Choroidal Neovascularization* / drug therapy
  • Choroidal Neovascularization* / etiology
  • Female
  • Fluorescein Angiography / methods
  • Humans
  • Intravitreal Injections
  • Osteoma* / complications
  • Osteoma* / diagnosis
  • Osteoma* / drug therapy
  • Tomography, Optical Coherence / methods
  • Vascular Endothelial Growth Factor A
  • Visual Acuity

Substances

  • Angiogenesis Inhibitors
  • Vascular Endothelial Growth Factor A
  • Bevacizumab