Recent advances of aggregation-induced emission materials for fluorescence image-guided surgery

Wei He; Zicong Zhang; Yumei Luo; Ryan Tsz Kin Kwok; Zheng Zhao; Ben Zhong Tang

doi:10.1016/j.biomaterials.2022.121709

Recent advances of aggregation-induced emission materials for fluorescence image-guided surgery

Biomaterials. 2022 Sep:288:121709. doi: 10.1016/j.biomaterials.2022.121709. Epub 2022 Aug 11.

Authors

Wei He¹, Zicong Zhang², Yumei Luo³, Ryan Tsz Kin Kwok⁴, Zheng Zhao⁵, Ben Zhong Tang⁶

Affiliations

¹ School of Science and Engineering, Clinical Translational Research Center of Aggregation-Induced Emission, School of Medicine, The Second Affiliated Hospital, The Chinese University of Hong Kong, Shenzhen, Guangdong, 518172, China; Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; HKUST Shenzhen Research Institute, No. 9 Yuexing 1st RD, South Area Hi-tech Park, Nanshan, Shenzhen, 518057, China; Center for Aggregation-Induced Emission and State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510640, China. Electronic address: wheaf@connect.ust.hk.
² School of Science and Engineering, Clinical Translational Research Center of Aggregation-Induced Emission, School of Medicine, The Second Affiliated Hospital, The Chinese University of Hong Kong, Shenzhen, Guangdong, 518172, China. Electronic address: 221019143@link.cuhk.edu.cn.
³ School of Science and Engineering, Clinical Translational Research Center of Aggregation-Induced Emission, School of Medicine, The Second Affiliated Hospital, The Chinese University of Hong Kong, Shenzhen, Guangdong, 518172, China. Electronic address: 360771021@qq.com.
⁴ Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; HKUST Shenzhen Research Institute, No. 9 Yuexing 1st RD, South Area Hi-tech Park, Nanshan, Shenzhen, 518057, China. Electronic address: chryan@ust.hk.
⁵ School of Science and Engineering, Clinical Translational Research Center of Aggregation-Induced Emission, School of Medicine, The Second Affiliated Hospital, The Chinese University of Hong Kong, Shenzhen, Guangdong, 518172, China; HKUST Shenzhen Research Institute, No. 9 Yuexing 1st RD, South Area Hi-tech Park, Nanshan, Shenzhen, 518057, China. Electronic address: zhaozheng@cuhk.edu.cn.
⁶ School of Science and Engineering, Clinical Translational Research Center of Aggregation-Induced Emission, School of Medicine, The Second Affiliated Hospital, The Chinese University of Hong Kong, Shenzhen, Guangdong, 518172, China; Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; HKUST Shenzhen Research Institute, No. 9 Yuexing 1st RD, South Area Hi-tech Park, Nanshan, Shenzhen, 518057, China; Center for Aggregation-Induced Emission and State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510640, China. Electronic address: tangbenz@cuhk.edu.cn.

PMID: 35995625
DOI: 10.1016/j.biomaterials.2022.121709

Abstract

Real-time intraoperative guidance is essential during various surgical treatment of many diseases. Aggregation-induced emission (AIE) materials have shown great potential for guiding surgeons during complex interventions, with the merits of deep tissue penetration, high quantum yield, high molar absorptivity, low background, good targeting ability and excellent photostability. Herein, we provided insights to design efficient AIE materials regarding three key parameters, i.e., deep-tissue penetration ability, high brightness of AIE luminogens (AIEgens), and precise tumor/other pathology nidus targeting strategies, for realizing better application of fluorescence image-guided surgery. Representative interdisciplinary achievements were outlined for the demonstration of this emerging field. Challenges and future opportunities of AIE materials were briefly discussed. The aim of this review is to provide a comprehensive view of AIE materials for intraoperative guidance for researchers and surgeons, and to inspire more further correlational studies in the new frontiers of image-guided surgery.

Keywords: Aggregation-induced emission; Fluorescence-guided surgery; Inflammatory treatments; NIR-II AIEgens; Precise tumor targeting.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Fluorescence
Fluorescent Dyes
Humans
Neoplasms*
Surgery, Computer-Assisted*

Substances

Fluorescent Dyes