Spreading of alpha-synuclein between different cell types

Wolfgang P Ruf; Joao L Meirelles; Karin M Danzer

doi:10.1016/j.bbr.2022.114059

Spreading of alpha-synuclein between different cell types

Behav Brain Res. 2023 Jan 5:436:114059. doi: 10.1016/j.bbr.2022.114059. Epub 2022 Aug 20.

Authors

Wolfgang P Ruf¹, Joao L Meirelles², Karin M Danzer³

Affiliations

¹ Department of Neurology, University Clinic, University of Ulm, Ulm, Germany.
² German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany.
³ Department of Neurology, University Clinic, University of Ulm, Ulm, Germany; German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany. Electronic address: karin.danzer@dzne.de.

PMID: 35995264
DOI: 10.1016/j.bbr.2022.114059

Abstract

Aggregation of alpha-synuclein (α-syn) is central in Parkinson's disease as well as in other synucleinopathies. Recent evidence suggests that not only intracellular aggregation of α-syn plays an important role for disease pathogenesis but also cell-to-cell propagation of α-syn seems to significantly contribute to pathological changes in synucleinopathies. In this mini-review we summarize current aspects of spreading of α-syn between brain cell types and its role in pathology.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Parkinson Disease* / metabolism
Synucleinopathies*
alpha-Synuclein / metabolism

Substances

alpha-Synuclein