Cerebral microvascular complications associated with SARS-CoV-2 infection: How did it occur and how should it be treated?

Neda Omidian; Pantea Mohammadi; Mona Sadeghalvad; Hamid-Reza Mohammadi-Motlagh

doi:10.1016/j.biopha.2022.113534

Cerebral microvascular complications associated with SARS-CoV-2 infection: How did it occur and how should it be treated?

Biomed Pharmacother. 2022 Oct:154:113534. doi: 10.1016/j.biopha.2022.113534. Epub 2022 Aug 17.

Authors

Neda Omidian¹, Pantea Mohammadi², Mona Sadeghalvad², Hamid-Reza Mohammadi-Motlagh³

Affiliations

¹ Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
² Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
³ Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: hamidreza.mohammadimotlagh@kums.ac.ir.

Abstract

Cerebral microvascular disease has been reported as a central feature of the neurological disorders in patients with SARS-CoV-2 infection that may be associated with an increased risk of ischemic stroke. The main pathomechanism in the development of cerebrovascular injury due to SARS-CoV-2 infection can be a consequence of endothelial cell dysfunction as a structural part of the blood-brain barrier (BBB), which may be accompanied by increased inflammatory response and thrombocytopenia along with blood coagulation disorders. In this review, we described the properties of the BBB, the neurotropism behavior of SARS-CoV-2, and the possible mechanisms of damage to the CNS microvascular upon SARS-CoV-2 infection.

Keywords: Blood-brain barrier; Cerebral microvascular; Inflammatory response; Neurological disorders; Neurotropism; SARS-CoV-2.

Publication types

Review

MeSH terms

Blood-Brain Barrier
Brain Diseases*
COVID-19* / complications
Endothelial Cells
Humans
Nervous System Diseases*
SARS-CoV-2