Endogenous siRNAs play important roles in silencing 'non-self' DNA elements but how the pathway distinguishes between self and non-self is unclear. In a new paper, Sam Gu and colleagues identify siRNA suppression as a mechanism for silencing 'self' siRNA. We caught up with the first authors, Zoran Gajic, Diljeet Kaur and Julie Ni, and the corresponding author, Sam Gu, Associate Professor at Rutgers University, to find out more about their research.
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