An outbreak of a novel recombinant Coxsackievirus A4 in a kindergarten, Shandong province, China, 2021

Juan Li; Nan Ni; Yanan Cui; Shuai Zong; Xue Yao; Tao Hu; Mengyuan Cao; Yong Zhang; Peiqiang Hou; Michael J Carr; Weijia Xing; Hong Zhou; Weifeng Shi

doi:10.1080/22221751.2022.2114855

An outbreak of a novel recombinant Coxsackievirus A4 in a kindergarten, Shandong province, China, 2021

Emerg Microbes Infect. 2022 Dec;11(1):2207-2210. doi: 10.1080/22221751.2022.2114855.

Authors

Juan Li¹, Nan Ni², Yanan Cui¹, Shuai Zong¹, Xue Yao¹, Tao Hu¹, Mengyuan Cao¹, Yong Zhang³, Peiqiang Hou², Michael J Carr^{4

5}, Weijia Xing¹, Hong Zhou¹, Weifeng Shi¹

Affiliations

¹ Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, People's Republic of China.
² Taian Center for Disease Control and Prevention, Taian, People's Republic of China.
³ Taishan District Center for Disease Control and Prevention, Taian, People's Republic of China.
⁴ National Virus Reference Laboratory, School of Medicine, University College Dublin, Dublin, Ireland.
⁵ International Collaboration Unit, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.

Abstract

In 2021, twenty children exhibiting influenza-like illnesses were reported from a kindergarten in Shandong Province, China. Eleven genomes of Coxsackievirus A4 (CV-A4) were obtained from the pediatric cases, sharing <93% genome sequence identities with known CV-A4 strains. Further analyses suggested potential genetic recombination in the P3 region of the novel strains.

Keywords: Coxsackievirus A4; enterovirus; outbreak; phylogenetic characterization; recombination.

Publication types

Letter

MeSH terms

Child
China / epidemiology
Disease Outbreaks*
Genotype
Hand, Foot and Mouth Disease* / epidemiology
Humans
Phylogeny

Grants and funding

This work was supported by the National Natural Science Foundation of China (81902065), and the Academic Promotion Programme of Shandong First Medical University (2019QL006).