AIE-active iridium(III) complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy

Shengnan Liu; Jiahong Han; Yulei Chang; Weijin Wang; Runlin Wang; Ziwei Wang; Guangzhe Li; Dongxia Zhu; Martin R Bryce

doi:10.1039/d2cc03622c

AIE-active iridium(III) complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy

Chem Commun (Camb). 2022 Sep 8;58(72):10056-10059. doi: 10.1039/d2cc03622c.

Authors

Shengnan Liu¹, Jiahong Han¹, Yulei Chang², Weijin Wang¹, Runlin Wang¹, Ziwei Wang¹, Guangzhe Li³, Dongxia Zhu¹, Martin R Bryce⁴

Affiliations

¹ Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province 130024, P. R. China. zhudx047@nenu.edu.cn.
² State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, Jilin Province 130033, China. yuleichang@ciomp.ac.cn.
³ Jilin Provincial Science and Technology Innovation Center of Health Food of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province 130117, P. R. China. 1993008106@qq.com.
⁴ Department of Chemistry, Durham University, Durham, DH1 3LE, UK. m.r.bryce@durham.ac.uk.

PMID: 35993197
DOI: 10.1039/d2cc03622c

Abstract

The integration of an aggregation induced emission (AIE)-active Ir(III) complex and upconversion nanoparticles (UCNPs) has achieved a NIR-irradiated photosensitizer (PS), UCNPs@Ir-2-N. This PS has satisfactory biocompatibility, excellent phototoxicity, good accumulation in cells and high ¹O₂ generation ability, thereby effectively killing 4T1 mouse cancer cells in vitro. This work has potential for future photodynamic therapy (PDT) applications.

MeSH terms

Animals
Iridium / pharmacology
Mice
Nanoparticles*
Photochemotherapy*
Photosensitizing Agents / pharmacology

Substances

Photosensitizing Agents
Iridium