Alphaherpesvirus glycoprotein E: A review of its interactions with other proteins of the virus and its application in vaccinology

Yaru Ning; Yalin Huang; Mingshu Wang; Anchun Cheng; Qiao Yang; Ying Wu; Bin Tian; Xumin Ou; Juan Huang; Sai Mao; Di Sun; Xinxin Zhao; Shaqiu Zhang; Qun Gao; Shun Chen; Mafeng Liu; Dekang Zhu; Renyong Jia

doi:10.3389/fmicb.2022.970545

Alphaherpesvirus glycoprotein E: A review of its interactions with other proteins of the virus and its application in vaccinology

Front Microbiol. 2022 Aug 4:13:970545. doi: 10.3389/fmicb.2022.970545. eCollection 2022.

Authors

Yaru Ning^{1

2

3}, Yalin Huang^{1

2

3}, Mingshu Wang^{1

2

3}, Anchun Cheng^{1

2

3}, Qiao Yang^{1

2

3}, Ying Wu^{1

2

3}, Bin Tian^{1

3}, Xumin Ou^{1

2

3}, Juan Huang^{1

2

3}, Sai Mao^{1

2

3}, Di Sun^{1

2

3}, Xinxin Zhao^{1

2

3}, Shaqiu Zhang^{1

2

3}, Qun Gao^{1

2

3}, Shun Chen^{1

2

3}, Mafeng Liu^{1

2

3}, Dekang Zhu^{2

3}, Renyong Jia^{1

2

3}

Affiliations

¹ Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China.
² Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China.
³ Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu, Sichuan, China.

Abstract

The viral envelope glycoprotein E (gE) is required for cell-to-cell transmission, anterograde and retrograde neurotransmission, and immune evasion of alphaherpesviruses. gE can also interact with other proteins of the virus and perform various functions in the virus life cycle. In addition, the gE gene is often the target gene for the construction of gene-deleted attenuated marker vaccines. In recent years, new progress has been made in the research and vaccine application of gE with other proteins of the virus. This article reviews the structure of gE, the relationship between gE and other proteins of the virus, and the application of gE in vaccinology, which provides useful information for further research on gE.

Keywords: alphaherpesvirus; glycoprotein E; interaction; vaccination; viral protein.

Publication types

Review