Management of Hepatitis B Virus Infection: 2018 Guidelines from the Canadian Association for the Study of Liver Disease and Association of Medical Microbiology and Infectious Disease Canada

Carla S Coffin; Scott K Fung; Fernando Alvarez; Curtis L Cooper; Karen E Doucette; Claire Fournier; Erin Kelly; Hin Hin Ko; Mang M Ma; Steven R Martin; Carla Osiowy; Alnoor Ramji; Edward Tam; Jean Pierre Villeneuve

doi:10.3138/canlivj.2018-0008

Management of Hepatitis B Virus Infection: 2018 Guidelines from the Canadian Association for the Study of Liver Disease and Association of Medical Microbiology and Infectious Disease Canada

Can Liver J. 2018 Dec 25;1(4):156-217. doi: 10.3138/canlivj.2018-0008. eCollection 2018 Fall.

Authors

Carla S Coffin¹, Scott K Fung², Fernando Alvarez³, Curtis L Cooper⁴, Karen E Doucette⁵, Claire Fournier⁶, Erin Kelly⁷, Hin Hin Ko⁸, Mang M Ma⁹, Steven R Martin¹⁰, Carla Osiowy¹¹, Alnoor Ramji¹², Edward Tam¹³, Jean Pierre Villeneuve⁶

Affiliations

¹ Cumming School of Medicine, University of Calgary, Calgary, Alberta.
² Faculty of Medicine, University of Toronto, Toronto, Ontario.
³ Centre hospitalier de l'université de Montréal (CHUM)-CHU Sainte-Justine, Montreal, Québec.
⁴ Division of Infectious Diseases, Department of Medicine, University of Ottawa, Ottawa, Ontario.
⁵ Division of Infectious Diseases, University of Alberta, Edmonton, Alberta.
⁶ Department of Medicine, Université de Montréal, Montreal, Québec.
⁷ Division of Gastroenterology, Department of Medicine, University of Ottawa, Ottawa, Ontario.
⁸ Faculty of Medicine, University of British Columbia, Vancouver, British Columbia.
⁹ Division of Gastroenterology, University of Alberta, Edmonton, Alberta.
¹⁰ Pediatrics, Alberta Children's Hospital, Calgary, Alberta.
¹¹ Viral Hepatitis and Bloodborne Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba.
¹² St. Paul's Hospital, Vancouver, British Columbia.
¹³ LAIR Centre, Vancouver, British Columbia.

Abstract

Hepatitis B virus (HBV) infection is an important public health problem in Canada. In keeping with evolving evidence and understanding of HBV pathogenesis, the Canadian Association for the Study of Liver Disease periodically publishes HBV management guidelines. The goals of the 2018 guidelines are to (1) highlight the public health impact of HBV infection in Canada and the need to improve diagnosis and linkage to care, (2) recommend current best-practice guidelines for treatment of HBV, (3) summarize the key HBV laboratory diagnostic tests, and (4) review evidence on HBV management in special patient populations and include more detail on management of HBV in pediatric populations. An overview of novel HBV tests and therapies for HBV in development is provided to highlight the recent advances in HBV clinical research. The aim and scope of these guidelines are to serve as an up-to-date, comprehensive resource for Canadian health care providers in the management of HBV infection.

Keywords: Association of Medical Microbiology and Infectious Disease (AMMI) Canada; Canadian Association for the Study of Liver Disease (CASL); guidelines; hepatitis B.