Bioavailability of xanthorrhizol following oral administration of a supercritical extract of Java turmeric

Juhyung Kang; Jihyun Won; Jae-Kwan Hwang; Wonku Kang

doi:10.1007/s10068-022-01124-w

Bioavailability of xanthorrhizol following oral administration of a supercritical extract of Java turmeric

Food Sci Biotechnol. 2022 Aug 6;31(10):1309-1313. doi: 10.1007/s10068-022-01124-w. eCollection 2022 Sep.

Authors

Juhyung Kang^#¹, Jihyun Won^#¹, Jae-Kwan Hwang², Wonku Kang¹

Affiliations

¹ College of Pharmacy, Chung-Ang University, Seoul, 06974 South Korea.
² Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722 South Korea.

^# Contributed equally.

Abstract

Although xanthorrhizol, a sesquiterpenoid oil obtained from the rhizome of Curcuma xanthorrhiza Roxb., known as Java turmeric, has many pharmacological effects, its pharmacokinetics remain unclear. Therefore, we investigated the pharmacokinetics of xanthorrhizol in mice and rats. Xanthorrhizol was administered intravenously and orally to mice, while xanthorrhizol and a Java turmeric supercritical extract were administered orally to rats. The terminal half-life (t_1/2), clearance, and absolute bioavailability (BA) of xanthorrhizol in mice were almost 8 h, 6.5 L/h/kg, and 10.2%, respectively. In comparison, the clearance of xanthorrhizol was 3-fold higher in rats than mice. The absolute BAs of xanthorrhizol in rats were 12.9% and 13.4% after oral administration of xanthorrhizol and a supercritical extract, respectively. Our results regarding the pharmacokinetics of xanthorrhizol could guide the conversion of intravenous and oral doses, and help identify the optimal maintenance doses of xanthorrhizol and the extract for desirable pharmacodynamic effects.

Keywords: Java turmeric extract; Mice; Pharmacokinetics; Rats; Xanthorrhizol.