Sarcoidosis-associated renal AA amyloidosis and crescentic necrotizing glomerulonephritis

Albert Bui; Cherise Cortese; Nabeel Aslam

doi:10.1080/08998280.2022.2072163

Sarcoidosis-associated renal AA amyloidosis and crescentic necrotizing glomerulonephritis

Proc (Bayl Univ Med Cent). 2022 May 16;35(5):680-682. doi: 10.1080/08998280.2022.2072163. eCollection 2022.

Authors

Albert Bui¹, Cherise Cortese², Nabeel Aslam³

Affiliations

¹ Department of Internal Medicine, Mayo Clinic, Jacksonville, Florida.
² Department of Pathology, Mayo Clinic, Jacksonville, Florida.
³ Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Jacksonville, Florida.

Abstract

Sarcoidosis has a rare and independent association with renal AA amyloidosis and crescentic necrotizing glomerulonephritis. However, coexisting entities in sarcoidosis have not been previously described. Herein, we report a 66-year-old Caucasian woman who presented with generalized fatigue, weight loss, and acute kidney injury in the setting of likely sarcoidosis. Renal biopsy revealed AA amyloid fibrils with fibrocellular crescents. The patient's clinical symptoms and laboratory results improved with high-dose glucocorticoids and azathioprine.

Keywords: AA amyloidosis; crescentic necrotizing glomerulonephritis; granulomas; sarcoidosis.

Publication types

Case Reports