Biodegradable Magnetic Molecularly Imprinted Anticancer Drug Carrier for the Targeted Delivery of Docetaxel

Zeeshan Ali; Muhammad Sajid; Suryyia Manzoor; Muhammad Mahboob Ahmad; Muhammad Imran Khan; Noureddine Elboughdiri; Muhammad Kashif; Abdallah Shanableh; Wajdi Rajhi; Wael Mersni; Emin Bayraktar; Sahbi Ben Salem

doi:10.1021/acsomega.2c03299

Biodegradable Magnetic Molecularly Imprinted Anticancer Drug Carrier for the Targeted Delivery of Docetaxel

ACS Omega. 2022 Aug 2;7(32):28516-28524. doi: 10.1021/acsomega.2c03299. eCollection 2022 Aug 16.

Affiliations

¹ Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60000, Pakistan.
² Research Institute of Sciences and Engineering (RISE), University of Sharjah, Sharjah 27272, United Arab Emirates.
³ Chemical Engineering Process Department, National School of Engineers Gabes, University of Gabes, Gabes 6011, Tunisia.
⁴ Department of Chemistry, Emerson University, Multan 60000, Pakistan.
⁵ Mechanical Engineering Department, College of Engineering, University of Ha'il, P.O. Box 2440, Ha'il 81441,Saudi Arabia.
⁶ National School of Engineers of Tunis, University of Tunis El Manar, Tunis 1068, Tunisia.
⁷ School of Mechanical and Manufacturing Engineering, ISAE-SUPMECA Institute of Mechanics of Paris, Saint-Ouen 93400, France.

Abstract

Molecularly imprinted biodegradable polymers are receiving considerable attention in drug delivery due to their ability of targeted recognition and biocompatibility. This study reports the synthesis of a novel fluorescence-active magnetic molecularly imprinted drug carrier (MIDC) using a glucose-based biodegradable cross-linking agent for the delivery of anticancer drug docetaxel. The magnetic molecularly imprinted polymer (MMIP) was characterized through scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction spectroscopy, and vibrating sample magnetometry (VSM). The MMIP presented a magnetization value of 0.0059 emu g^-1 and binding capacity of 72 mg g^-1 with docetaxel. In vitro and in vivo studies were performed to observe the effectiveness of the MIDC for drug delivery. The cell viability assay suggested that the MMIP did not present toxic effects on healthy cells. The magnetic property of the MMIP allowed quick identification of the drug carrier at the target site by applying the external magnetic field to mice (after 20 min of loading) and taking X-ray images. The novel MMIP-based drug carrier could thus deliver the drug at the target site without affecting the healthy cells.