Mixed Germ Cell Tumor with a Yolk Sac Tumor Component in the Medulla Oblongata of a 50-year-old Patient: A Case Report and Literature Review

Intern Med. 2023 Mar 15;62(6):915-921. doi: 10.2169/internalmedicine.9447-22. Epub 2022 Aug 20.

Abstract

Yolk sac tumor (YST) is a rare primary brain tumor that occurs almost exclusively in patients under 30 years old. Intracranial germ cell tumors are most frequently located in the pineal and suprasellar region. Medulla oblongata YSTs are particularly rare. Extragonadal YSTs may be difficult to diagnose because of their characteristics, such as the rarity and variety of growth patterns. Furthermore, they are known to have a very poor prognosis. We herein report a case of YST of the medulla oblongata in a 50-year-old woman. She was followed up for 18 months without any tumor recurrence.

Keywords: germ cell tumor; medulla oblongata; yolk sac tumor.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Adult
  • Endodermal Sinus Tumor* / diagnosis
  • Endodermal Sinus Tumor* / pathology
  • Female
  • Humans
  • Medulla Oblongata / diagnostic imaging
  • Medulla Oblongata / pathology
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Neoplasms, Germ Cell and Embryonal* / diagnostic imaging
  • Skull