Glycine-bound NMDA receptors are stretch-activated

Trends Neurosci. 2022 Nov;45(11):794-795. doi: 10.1016/j.tins.2022.08.002. Epub 2022 Aug 18.

Abstract

In a recent study, Belin et al. demonstrated that glycine-bound NMDA receptors can be activated by mechanical forces in the absence of the neurotransmitter glutamate. The stretch-gated receptor exhibits biophysical properties similar to those of glutamate-gated receptors. These findings reveal that glycine-bound NMDA receptors could behave as mechanosensors in central nervous system (CNS) physiology.

Keywords: NMDA receptors; mechanically activated ion channels; mechanosensation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Glutamates
  • Glycine
  • Humans
  • Neurotransmitter Agents
  • Receptors, Glutamate
  • Receptors, Glycine*
  • Receptors, N-Methyl-D-Aspartate*

Substances

  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Glycine
  • Glycine
  • Receptors, Glutamate
  • Glutamates
  • Neurotransmitter Agents