Towards establishing human body-on-a-chip systems

Zhong Alan Li; Rocky S Tuan

doi:10.1186/s13287-022-03130-5

Towards establishing human body-on-a-chip systems

Stem Cell Res Ther. 2022 Aug 20;13(1):431. doi: 10.1186/s13287-022-03130-5.

Authors

Zhong Alan Li¹, Rocky S Tuan²

Affiliations

¹ Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
² Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China. tuanr@cuhk.edu.hk.

Abstract

Body-on-a-chip (BoC) platforms are established from multiple organs-on-chips (OoCs) to recapitulate the interactions between different tissues. Recently, Vunjak-Novakovic and colleagues reported the creation of a BoC system comprising four fluidically linked OoCs. Herein, the major innovations in their BoC system are discussed, followed by our future perspectives on enhancing the physiological relevance and scalability of BoCs for applications in studying disease mechanisms, testing potential therapeutics, and developing personalized medicine.

Keywords: Body-on-a-chip; Disease modelling; Drug testing; Microfluidic device; Organ-on-a-chip; Patient-on-a-chip; Precision medicine; Stem cell.

Publication types

Letter
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Human Body*
Humans
Lab-On-A-Chip Devices*
Precision Medicine