A plant immune protein fights against cancer

Rong Chen; Jianqiang He; Zhaoliang Su; Jian Chen

doi:10.1016/j.tibs.2022.08.001

A plant immune protein fights against cancer

Trends Biochem Sci. 2022 Dec;47(12):996-998. doi: 10.1016/j.tibs.2022.08.001. Epub 2022 Aug 18.

Authors

Rong Chen¹, Jianqiang He², Zhaoliang Su³, Jian Chen⁴

Affiliations

¹ Department of Nephrology, Affiliated Hospital of Jiangsu University, Zhenjiang 212013, China; International Genome Center, Jiangsu University, Zhenjiang 212013, China; Department of Clinical Laboratory, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 20130, China.
² Department of Nephrology, Affiliated Hospital of Jiangsu University, Zhenjiang 212013, China.
³ International Genome Center, Jiangsu University, Zhenjiang 212013, China. Electronic address: SZL30@ujs.edu.cn.
⁴ International Genome Center, Jiangsu University, Zhenjiang 212013, China. Electronic address: jianchen@ujs.edu.cn.

PMID: 35985942
DOI: 10.1016/j.tibs.2022.08.001

Abstract

Altered global miRNA abundance is closely related to the occurrence of cancer. Recently, Qi et al. discovered that abnormal 1-nucleotide (nt)-shorter miRNA isoforms are widely accumulated in different human tumors. Ectopic expression of the plant immune protein RNA-dependent RNA polymerase (RDR)-1 can achieve a broad-spectrum antitumor effect by rescuing miRNA defects in cancer cells.

Keywords: RNA-dependent RNA polymerase 1 (RDR1); antitumor; cancer; miRNA; nucleotidyltransferase.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
MicroRNAs* / genetics
Neoplasms*
Plant Proteins / genetics
Plant Proteins / metabolism
RNA-Dependent RNA Polymerase

Substances

Plant Proteins
RNA-Dependent RNA Polymerase
MicroRNAs