Clinical efficacy of oligonol® supplementation on metabolism and muscle health in middle-aged and older adults: A double-blinded randomized controlled trial

Li-Ning Peng; Ming-Hsien Lin; Huei-Fang Lee; Chia-Chia Hsu; Sue-Joan Chang; Liang-Kung Chen

doi:10.1016/j.archger.2022.104784

Clinical efficacy of oligonol® supplementation on metabolism and muscle health in middle-aged and older adults: A double-blinded randomized controlled trial

Arch Gerontol Geriatr. 2022 Nov-Dec:103:104784. doi: 10.1016/j.archger.2022.104784. Epub 2022 Jul 31.

Authors

Li-Ning Peng¹, Ming-Hsien Lin², Huei-Fang Lee³, Chia-Chia Hsu⁴, Sue-Joan Chang⁵, Liang-Kung Chen⁶

Affiliations

¹ Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Rd., Taipei 11217, Taiwan; Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, No. 1001, Daxue Rd. East Dist., Hsinchu 300093, Taiwan. Electronic address: lining.peng@gmail.com.
² Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Rd., Taipei 11217, Taiwan; Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, No. 1001, Daxue Rd. East Dist., Hsinchu 300093, Taiwan.
³ Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, No. 1001, Daxue Rd. East Dist., Hsinchu 300093, Taiwan.
⁴ Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Rd., Taipei 11217, Taiwan.
⁵ Department of Life Sciences, National Cheng Kung University, Tainan, Taiwan.
⁶ Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Rd., Taipei 11217, Taiwan; Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, No. 1001, Daxue Rd. East Dist., Hsinchu 300093, Taiwan; Taipei Municipal Gan-Dau Hospital (Managed by Taipei Veterans General Hospital), Taipei, Taiwan.

PMID: 35985196
DOI: 10.1016/j.archger.2022.104784

Abstract

Background: Oligonol® is a low-molecular-weight polyphenol that has biological effects on metabolism in animals. However, little is known about its roles in muscle function and muscle quality in middle-aged and older adults.

Methods: 120 participants were enrolled for study based on 1:1 randomization. Participants in the intervention group were provided 200 mg oligonol® prepared as capsules, and 200 mg placebo (dextrin) was provided in control group.

Results: Data from 103 participants (52 in the intervention group and 51 in the control group) were available for analysis. The mean age of all participants was 64.0 ± 8.2 years, and two-thirds of the participants were females. Baseline demographic characteristics, functional assessment, laboratory data and muscle parameters were similar between groups. Hip circumference decreased (p = 0.009) during the study period, and the 6-m walking speed increased (p = 0.001) in women in the intervention group. In contrast, 6-m walking speed, 6-min walking distance and handgrip strength were significantly improved in men in the intervention group, but increased total body fat percentage (p = 0.038) and decreased mid-thigh cross-muscle area (CMA) (p = 0.007) were observed in the control group. Compared to the control group, the 12-week interval change in the percentage of mid-thigh CMA was maintained in men in the intervention group but was significantly decreased in the control group (p = 0.03, 95% CI:0.002-0.05).

Conclusions: Oligonol supplementation (200 mg per day) significantly improved physical performance and muscle mass in men. Further studies are needed to confirm the potential favorable effects of oligonol® supplementation.

Keywords: Metabolism; Muscle health; Older adults; Oligonol®.