Heterosynthons, Solid Form Design and Enhanced Drug Bioavailability

Abstract

Starting from a molecular pharmacophore, which is a marker of drug action in medicinal molecules, we propose that the heterosynthon, a supramolecular synthon between unlike functional groups, plays an analogous role in the design and discovery of high bioavailability drugs. The heterosynthon could provide a more efficient and economical route to novel drugs.

Keywords: cocrystals; crystal engineering; drug discovery; pharmaceutical development; supramolecular synthons.