Atogepant is a selective oral, small-molecule calcitonin gene-related peptide (CGRP) receptor antagonist that has been approved for preventive treatment of migraine. CGRP is a neuropeptide involved in vasodilation and cerebrovascular regulation. CGRP is the most potent vasoactive constituent of the cerebrovascular trigeminal neuronal system and has a key role in migraine. Medications targeting CGRP are being used as migraine preventive and abortive treatments.
Keywords: Analgesic drugs; Antimigraine drugs; Atogepant; Calcitonin gene-related peptide (CGRP) receptor antagonists; Gepants; Migraine with aura; Migraine without aura.
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