Immunosenescence, aging and successful aging

Yunan Wang; Chen Dong; Yudian Han; Zhifeng Gu; Chi Sun

doi:10.3389/fimmu.2022.942796

Immunosenescence, aging and successful aging

Front Immunol. 2022 Aug 2:13:942796. doi: 10.3389/fimmu.2022.942796. eCollection 2022.

Authors

Yunan Wang¹, Chen Dong², Yudian Han³, Zhifeng Gu², Chi Sun⁴

Affiliations

¹ Department of Rheumatology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
² Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong, China.
³ Information Center, The First People's Hospital of Nantong City, Nantong, China.
⁴ Department of Geriatrics, Affiliated Hospital of Nantong University, Nantong, China.

Abstract

Aging induces a series of immune related changes, which is called immunosenescence, playing important roles in many age-related diseases, especially neurodegenerative diseases, tumors, cardiovascular diseases, autoimmune diseases and coronavirus disease 2019(COVID-19). However, the mechanism of immunosenescence, the association with aging and successful aging, and the effects on diseases are not revealed obviously. In order to provide theoretical basis for preventing or controlling diseases effectively and achieve successful aging, we conducted the review and found that changes of aging-related phenotypes, deterioration of immune organ function and alterations of immune cell subsets participated in the process of immunosenescence, which had great effects on the occurrence and development of age-related diseases.

Keywords: age-related diseases; centenarian; immunosenescence; inflammation; successful aging.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Autoimmune Diseases*
COVID-19*
Humans
Immunosenescence*
Neurodegenerative Diseases*