Protective Effect of the Chinese Herb Draba Scabra on the Sepsis Myocarditis in Molecular Mechanism

Xiaoxin Gao; Rujun Zhang; Fuxing Hu; Qingan Chen; Zhenlin Lei; Yanan Yang; Jia Tian; Ling Huang

doi:10.1155/2022/2313813

Protective Effect of the Chinese Herb Draba Scabra on the Sepsis Myocarditis in Molecular Mechanism

Evid Based Complement Alternat Med. 2022 Aug 9:2022:2313813. doi: 10.1155/2022/2313813. eCollection 2022.

Authors

Xiaoxin Gao¹, Rujun Zhang², Fuxing Hu³, Qingan Chen¹, Zhenlin Lei¹, Yanan Yang¹, Jia Tian¹, Ling Huang^{4

5

6

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Affiliations

¹ Intensive Medical Unit, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
² Department of Cardiology, Hainan Province Clinical Medical Center, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.
³ Intensive Medical Unit, Hainan Second People's Hospital, Wuzhishan, China.
⁴ Hainan Province Key Laboratory for Drug Preclinical Study of Pharmacology and Toxicology Research, Hainan Medical University, Haikou, China.
⁵ School of Hainan Provincial Drug Safety Evaluation Research Center, Hainan Medical University, Haikou, China.
⁶ Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Medical University, Haikou, China.
⁷ Research Unit of Island Emergency Medicine, Chinese Academy of Medical Science, Hainan Medical University, Haikou, China.

Abstract

Objective: The aim of this study was to observe the efficacy and mechanism of Draba scabra in sepsis myocarditis.

Methods: The efficacy and pathways of action of Draba scabra on septic myocarditis were evaluated by making a rat model of sepsis with appendix perforation, using Draba scabra for pharmacological intervention, and measuring serum inflammatory factors, cardiac function indexes and parameters, and P38 protein expression in each group of rats, respectively.

Results: The inflammatory factor level, apoptotic index of cardiomyocytes, and P38-MARK protein were significantly higher, while the cardiac function index and hemodynamic index were significantly decreased in group B, while the opposite was true in group E. The treatment was also found to be dose-dependent.

Conclusion: Draba scabra pretreatment effectively reduces the inflammatory response and improves hemodynamic indexes in septic rats. The mechanism may be via the P38-MARK pathway to protect the myocardium.