Case Report: A rare case of familial lung cancer requiring pneumonectomy in three male siblings

Andrey Kaprin; Oleg Pikin; Andrey Ryabov; Oleg Aleksandrov; Evgeniy Toneev; Ludmila Lubchenko; Ekaterina Zelenova

doi:10.3389/fonc.2022.947210

Case Report: A rare case of familial lung cancer requiring pneumonectomy in three male siblings

Front Oncol. 2022 Aug 2:12:947210. doi: 10.3389/fonc.2022.947210. eCollection 2022.

Authors

Andrey Kaprin^{1

2}, Oleg Pikin¹, Andrey Ryabov¹, Oleg Aleksandrov¹, Evgeniy Toneev³, Ludmila Lubchenko¹, Ekaterina Zelenova²

Affiliations

¹ P.Herzen Moscow Oncology Research Institute (MORI), Moscow, Russia.
² Peoples' Friendship University of Russia, Moscow, Russia.
³ Ulyanovsk Oncology Center, Ulyanovsk, Russia.

Abstract

Lung cancer is a disease with a unique genetic pattern and is occasionally related to hereditary syndromes such as Lynch, Louis-Bar, and Li-Fraumeni. In some patients, germinal mutations may be discovered in combination with somatic alterations. For instance, Li-Fraumeni syndrome often reveals a mixture of TP53 and EGFR mutations. The development of new target therapies necessitates an extensive search for new pathogenic mutations. In this article, we present a rare case report of lung cancer, requiring a pneumonectomy, in three sibling brothers.

Keywords: familial cancer; genome sequencing; immunotherapy; lung cancer; pneumonectomy.

Publication types

Case Reports