Effect of vitamin C supplement on lead bioaccessibility in contaminated soils using multiple in vitro gastrointestinal assays: Mechanisms and health risks

Naiyi Yin; Zeliang Han; Wenbin Jia; Yaqi Fu; Jingnan Ma; Xiaotong Liu; Xiaolin Cai; Yan Li; Xiaochen Chen; Yanshan Cui

doi:10.1016/j.ecoenv.2022.113968

Effect of vitamin C supplement on lead bioaccessibility in contaminated soils using multiple in vitro gastrointestinal assays: Mechanisms and health risks

Ecotoxicol Environ Saf. 2022 Sep 15:243:113968. doi: 10.1016/j.ecoenv.2022.113968. Epub 2022 Aug 15.

Authors

Naiyi Yin¹, Zeliang Han², Wenbin Jia³, Yaqi Fu⁴, Jingnan Ma⁴, Xiaotong Liu¹, Xiaolin Cai¹, Yan Li⁵, Xiaochen Chen⁶, Yanshan Cui⁷

Affiliations

¹ College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China; Research Center for Eco-Environment Sciences, Chinese Academy of Sciences, Beijing 100085, China.
² College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China; Fujian Provincial Engineering Research Center of Rural Waste Recycling Technology, College of Environment and Safety Engineering, Fuzhou University, Fuzhou 350108, China.
³ National Research Center for Geoanalysis, Chinese Academy of Geological Sciences, Beijing 100037, China. Electronic address: zzkcjiawenbin@mail.cgs.gov.cn.
⁴ College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China; Sino-Danish Centre for Education and Research, University of Chinese Academy of Sciences, Beijing 101408, China.
⁵ Department of Agricultural, Forest and Food Sciences, University of Turin, Torino 10095, Italy.
⁶ Fujian Provincial Engineering Research Center of Rural Waste Recycling Technology, College of Environment and Safety Engineering, Fuzhou University, Fuzhou 350108, China.
⁷ College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China; Research Center for Eco-Environment Sciences, Chinese Academy of Sciences, Beijing 100085, China. Electronic address: cuiyanshan@ucas.ac.cn.

PMID: 35981483
DOI: 10.1016/j.ecoenv.2022.113968

Abstract

Effects of vitamin C supplementation on the oral bioaccessibility of lead (Pb) present in contaminated soils were examined using a number of in vitro assays (PBET, SBRC, UBM and IVG). In the presence of vitamin C, an increase in Pb bioaccessibility was observed in the gastric phase by 1.3-fold (30.5%-85.5%) and in the intestinal phase by 3.1-fold (0.9%-58.9%). Lead mobilization was regulated by reductive dissolution of Fe(III) and sequestration of Pb on secondary Fe minerals. Sequential extraction by the Bureau Community of Reference (BCR) provided more evidence that reducible fraction and residual fraction were major contributor of gastric Pb bioaccessibility, as well as reduced fractions in intestinal Pb bioaccessibility. In addition, higher non-carcinogenic risks may occur based on target hazard quotient (THQ ≥ 1). For people exposed to Pb present in soil, the management of vitamin C supplements is of serious concern.

Keywords: Bioaccessibility; Health risk; Iron, vitamin C; Lead.

MeSH terms

Ascorbic Acid
Biological Availability
Dietary Supplements
Ferric Compounds
Humans
Lead / toxicity
Soil
Soil Pollutants* / analysis

Substances

Ferric Compounds
Soil
Soil Pollutants
Lead
Ascorbic Acid